Downstream Senior Scientist Group Lead

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Job description

Consider joining Lancaster Laboratories where people are the most important element in our chemistry. Celebrating 50 years of service, Lancaster Laboratories is a leading contract lab providing testing and research services in the environmental, pharmaceutical, and biopharmaceutical sciences to clients worldwide.

Job Description

Eurofins Lancaster Laboratories, a nationally recognized laboratory, is searching for an experienced Scientist to work in our Professional Scientific Services group in Emeryville, California. The primary purpose of this position is to work with Senior and Junior level associates to develop robust Downstream processes in support of developing and optimizing production processes including process parameter optimization, process characterization, scale-up/tech transfer for large scale product production and support successful implementation of production processes at commercial scale.

PRIMARY JOB RESPONSIBILITIES:

• Demonstrate ability to learn new techniques, work with Senior level associates to solve problems, prepare technical reports; and evaluate new instrumentation or process techniques
• Executes laboratory-based studies, analyzes and interprets results, participates in process improvement, development, and qualification activities
• Executes complex scientific protocols in a highly coordinated team environment from preparation, testing, and data analysis
• Authors procedures/protocols or technical reports that include data interpretation
• Prepares and effectively communicates technical results in cross-functional settings
• Ensure their own experimental and testing work is performed as defined in the approved study protocols or SOPs/guidelines
• A flexible schedule with the ability to do some shift work and availability on weekends
• Maintains laboratory facilities and equipment in accordance with company policies and industrial best practices
• Maintaining the labs in a clean, safe, and organized manner to ensure efficient performance of activities
• Coordinating vendor visits for onsite service, work with instrumentation group for other calibration events
• Troubleshoot, repair, clean and operate equipment, as needed
• Improve laboratory practices to increase throughput and decrease errors

THE IDEAL CANDIDATE WOULD POSSESS:

• Has technical/scientific knowledge of biopharmaceutical processes, at both process development and/or manufacturing scales of operation
• Technical expertise in protein purification of derived recombinant proteins and monoclonal antibodies
• Support efforts for developing and optimizing downstream processes including process parameter optimization, process characterization and scale-up/tech transfer for large scale product production
• Hands-on experience in modern protein purification techniques (chromatography, affinity, ion-exchange, hydrophobic, mixed mode, experience working with AKTA, Unicorn, clarification/filtration, ultrafiltration/diafiltration) are required
• Execute protocols ranging from resin screening, chromatography, filter sizing and TFF optimization
• Working knowledge of AKTA Avant and Pilot systems and associated software, AKTA Unicorn and Assist software
• Working knowledge and ability to program Unicorn and Assist Plate Reader software or an equivalent
• Knowledge of process scale-up and scale-down methodologies, including process characterization and design of experiments
• Understanding of basic statistical data analysis and a willingness to explore advanced statistical modelling tools
• Attention to detail, strong organizational skills, the ability to multitask, and effective interpersonal and communication skills are required
• Capable of representing the functional area on a cross-functional team and presenting technical data at team meetings
• Must have good planning and organizing skills, manage time effectively by prioritizing tasks, taking the initiative to solve problems quickly, and knowing when to obtain assistance
• Proficient with the use of MS Office software (MS Excel, MS Word, MS Powerpoint) and application software (not limited to) including Unicorn, JMP, Minitab, Design Expert etc)

Qualifications

• Educational degrees must be relevant to position (e.g., Biology, Biochemistry, Chemistry, or Toxicology): PhD 0-2 yrs of experience, MS +3 yrs of experience, or BS +6 yrs of experience
• Experience in cGMP and large-scale manufacturing equipment and operations is a plus

Additional Information

What we offer:

• Excellent full time benefits including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Position is full-time, 8am - 5pm with ocassional overtime required. Candidates currently living within a commutable distance of Emeryville, California are encouraged to apply.

Eurofins Lancaster Laboratories Professional Scientific Services® (PSS) is a global, award-winning insourcing solution that places our people at our clients' site dedicated to running and managing laboratory services while eliminating headcount, co-employment and project-management worries.

We infuse our 55-year track record of scientific and laboratory operations expertise, as well as HR and great place to work best practices, to recruit, hire, train and manage highly qualified scientists to perform laboratory services using our client's quality systems and equipment.

Eurofins is a M/F, Disabled, and Veteran Equal Employment Opportunity and Affirmative Action employer.