Research Associate, Antibody Discovery

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Job description

We are seeking a highly motivated individual to join as a Senior Research Associate/Scientist I in the Antibody Discovery team. The successful candidate will contribute to our efforts for the discovery of therapeutic monoclonal antibodies from immune cells using all available means but with a strong focus on using single B cell technologies. The successful candidate will be expected to work independently to oversee and deliver on projects against a variety of targets.

Responsibilities:

· Execute antibody discovery campaigns to generate monoclonal antibodies using B-cell technology platforms, including animal immunizations, single B cell sorting, culturing, and functional screening.

· Evaluate serum titres, harvest spleen, and lymph nodes, and perform single B cell sorting using various strategies including antigen-directed cell sort.

· Screen and characterize antibodies for binding and functional activity using ELISA, Flow cytometry, biochemical and cell-based assays, and biomolecular interaction technologies such as SPR or BLI

· Perform small-scale antibody expression and purification of antibodies.

· Explore new technologies, opportunities and automation to improve and/or streamline the antibody discovery workflow and process.

· Provide regular progress updates to the project teams and help optimize the antibody discovery workflow.

Requirements:

· MS in Molecular Biology, Biochemistry, Immunology, or related field with 3+ years industry experience; or BS with 5+ years of industry experience with a strong prior track record of success.

· Ideal candidates will have prior experience in single B-cell (i.e., B cell cloning)-based antibody discovery workflows to identify novel therapeutic candidates.

· Hands-on experience with cell biology including mammalian cell culture, transfection, and running functional cell-based assays is a must.

· Hands-on experience with protein-protein interaction using a variety of methods such as ELISA, Flow cytometry, Bio-Layer Interferometry (Octet) is a must.

· Experience with molecular biology techniques is highly desirable and preferred.

· Experience with automation and high throughput assay development is highly desirable.

· Detail-oriented with proven ability to troubleshoot complex problems with diverse variables.