Associate Scientist- Process Development

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Job description

At Alector, our mission is to develop therapies that empower the immune system to cure neurodegeneration. Our team is solely focused on developing cures for some of the most challenging diseases facing our society. We are supported in this mission by experienced and accomplished scientists and board members, leading healthcare investors and some of the most innovative pharma companies.

Would you like to take part in creating new therapies that really make a difference in patients' lives? Do you desire both autonomy and collaboration in taking on scientific challenges that interest you? Be part of a hardworking team where everyone has a voice!

Use your scientific skills to help us achieve our mission of saving lives by curing neurodegenerative diseases.

As an Associate Scientist, you will be part of our Downstream Process Development team where you will work closely with members from the Upstream and Analytical Development teams. This role is part of a cross-functional team, requiring you to communicate and work well with multiple departments, including Preclinical and Research teams. Alector is seeking a candidate with experience purifying protein biomolecules. The successful candidate will have in-depth experience of industry-standard chromatography methods and possess practical knowledge of development. You will be in charge of purifying research biomolecules to support drug discovery efforts and support the development of product-specific, purification processes for Alector's lead molecules. You will identify and provide support for ongoing programs and your work will be central to Alector's strategic goals. You will be influential in championing and developing Alector's culture.

We'd love to hear from you if you have:

• B.S. degree in related scientific field with 8-12 years of relevant industry experience OR M.S degree with 4-8 years of relevant industry experience
• Hands-on experience purifying various proteins using AKTA FPLC systems; experience purifying monoclonal antibodies and bi-specific molecules is highly desirable
• Mastery of Unicorn software and ability to author and customize purification methods for various techniques is a must
• Must possess a high degree of technical competence of industry-standard techniques and methods for the purification of antibodies such as: Protein A affinity chromatography, IEX chromatography, HIC chromatography, mixed mode chromatography, and UF/DF, TFF, and formulation unit operations
• Strong organization skills in experiment recording and data summary with strong attention to detail
• Apply knowledge and skill to independently problem-solve and devise new methods and/or optimize existing methods to purify difficult proteins
• Excellent project management and organizational skills with the ability to prioritize multiple work streams and deadlines, balance opposing priorities and communicate effectively
• Excellent interpersonal, verbal and written communication skills are essential in our collaborative work environment

Responsibilities

• Support in-house, large-scale material generation in support of non-GMP studies
• Purification of murine and humanized antibodies, bi-specific molecules, and fusion proteins using single or multi-step chromatography step(s)
• Support in reviewing and editing of various development reports like Process Descriptions, stability reports, and Purification Process Development reports
• Executing Batch Production Records and following purification SOPs for large-scale purification workflows
• Contribute to expanding internal development capabilities by researching new technologies and instrumentation, and staying current with industry trends
• Design, execute and analyze complex purification development experiments with minimal supervision is a must
• Additional desirable skills: experience with basic analytical assays (e.g. SDS-PAGE, SEC-HPLC, UV-Vis, LAL), liquid protein formulation development, and large-scale purification

At Alector, we believe that high-performing teams include people from a wide variety of backgrounds and experiences who can challenge each other's assumptions with fresh perspectives and bring creative ideas to the table. We are committed to building an open, diverse, and inclusive environment for all employees. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, sexual orientation, age, marital status, veteran status, disability status, or any other characteristics protected under applicable federal, state, or local laws.

Alector is a great place to learn and experiment. If you excel in a dynamic environment where everyone is committed to finding a cure, where you'll drive growth, this is the role for you. There is no limit to how far you can go with us.

Benefits

While we've focused on what to look forward to during the first year and beyond, Day One is great, too: committed and driven colleagues, a bold and important company goal, state-of-the-art brand-new brightly-lit offices in the heart of the biotech area, competitive compensation and benefits. But these matter only if you're excited to build and own something great, and take on these challenges with us. Come join us.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.