Scientist, Histopathology

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Job description

At Bristol Myers Squibb, we are inspired by a single vision transforming patients lives through science.In oncology, hematology, immunology and cardiovascular disease and one of the most diverse and promising pipelines in the industry each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines, we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

Position Summary:

We are seeking a highly motivated and talented individual to join the Immunohistochemistry (IHC) team in the Translational Research Group at Bristol Myers Squibb (Redwood City, CA). The Scientist will be part of a team dedicated to developing various tissue-based assays to drive discovery programs and enable translational biomarker strategies in multiple oncology programs. The ideal candidate will possess in-depth histopathology laboratory skills and experience, including tissue grossing, processing and embedding, automated IHC staining, IHC validation research using IHC markers for bright field and multiplexed immunofluorescence (IF) assays. He/she will also have effective communication skills in English, ability to work in a matrixed-based, fast paced environment, solid problem-solving abilities, excellent organizational skills, attention to detail and a commitment to excellence.

Duties & Responsibilities will include, but are not limited to, the following:

• Perform assigned histology and IHC staining work independently by organizing own workload and following study protocols, including rodent tissue grossing, operating automated tissue processors, performing paraffin embedding of tissue and cell pellet blocks, performing IHC, in situ hybridization and multiplexed IF staining using autostainers and scanning stained slides; produce high quality histological/IHC slides and complete all study activities on time

• Perform all work efficiently in a safe manner and in compliance with applicable regulations

• Perform routine preventative maintenance, cleaning, and minor adjustments on lab equipment; demonstrate ability to trouble-shoot equipment without supervision

• Document all work activities and maintain all assigned study records in accordance with study protocols by following company policies, using current forms and procedures, making all entries legibly, accurately and contemporaneously in a timely fashion

• Provide training and technical support to team members when needed

• May perform digital quantification of IHC staining for in vivo studies

• Retrieve and store specimens properly for long term storage; organize and maintain archived histological slides and blocks

• Order laboratory supplies to maintain proper inventory

• Effectively collaborate in highly matrixed organization as a team player

• Perform other duties as assigned

Requirements:

• Bachelors degree from an accredited institution in Biological Sciences or related Biomedical fields with over 8 years of experience or Masters degree with over 5 years experience in histotechnology in an industry or academic/clinic core lab

• Extensive hands-on histopathology laboratory experience, including mouse tissue grossing, operating automated tissue processors, performing paraffin embedding, performing IHC and in situ hybridization using autostainers (Leica Bond, Ventana, DAKO, etc.), and operating whole-slide scanners (Leica AT2, etc.)

• Extensive experience in FFPE microtome and frozen tissue cryostat sectioning

• American Society of Clinical Pathology certified Histotechnician (HT) or Histotechnologist (HTL) is required

• Experience in IHC antibody validation and IHC assay development is highly desirable

• Experience with digital pathology and image analysis software (HALO, etc.)

• Experience with Microsoft Office software suit (Excel, Word, PowerPoint, Outlook)

• Excellent organizational skills and attention to detail

• Ability to work independently under minimal supervision

• Effective written and verbal communication skills in English

• Familiarity with a matrixed based, fast-paced work environment

• Collaborative/team spirit and ability to thrive in a matrixed environment

• Self-motivated and eager to learn new skills and technologies

• Be able to work in a seated position for an extended duration (~2h), with periodic breaks, while performing routine histotechnology functions (eg., tissue trimming, embedding, microtomy, etc)

• Some knowledge of cancer biology is a plus

BMSONCRD, BMSDDTMRCA

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to . Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

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