Sr. Bioinformatics Scientist, Machine Learning (Redwood City, CA OR San Diego, CA OR Seattle, WA)

Guardant Health is a leading precision oncology company focused on helping conquer cancer globally through use of its proprietary blood tests, vast data sets and advanced analytics. The Guardant Health Oncology Platform leverages capabilities to drive commercial adoption, improve patient clinical outcomes and lower healthcare costs across all stages of the cancer care continuum. Guardant Health has launched liquid biopsy-based Guardant360®, Guardant360 CDx and GuardantOMNI® tests for advanced stage cancer patients. These tests fuel development of its LUNAR program, which aims to address the needs of early-stage cancer patients with neoadjuvant and adjuvant treatment selection, cancer survivors with surveillance, asymptomatic individuals eligible for cancer screening and individuals at a higher risk for developing cancer with early detection.

At Guardant Health, we are committed to positively and significantly impacting patient health through technology breakthroughs that address long-standing unmet needs in oncology. As the leader in the field of liquid biopsy, Guardant Health has collected cancer genomic data from over 100,000 patients and is looking for bioinformatics scientists excited about analyzing genetic and epigenetic signals in this data to enable breakthroughs in cancer patient care by developing an assay for detection of cancer at an early stage. We are working at the forefront of scientific and technological developments with emphasis on results that enable clinical impact on real patients and you will contribute to this effort.

Here are some of our recent published results:

• #!/6812/presentation/4801

and the press release about the launch of 10,000-patient trial for evaluating the clinical impact of LUNAR blood test to detect colorectal cancer on average-risk population:

RESPONSIBILITIES

• Develop, prototype, and analyze the performance of novel statistical models
• Explore and elucidate signals relevant to early cancer detection from large-scale NGS data
• Participate in brainstorming sessions, maintain a highly productive and interactive work environment
• Communicate analysis results to stakeholders across computational and experimental teams
• Develop reproducible analyses for research and development activities
• Provide written documentation and specifications

ABOUT YOU

• Dedicated to making a difference in a rapid-paced startup environment
• Ph.D. in computational biology/bioinformatics, genomics, machine learning, or related fields + 3 years of relevant experience
• Strong statistical fundamentals, especially in Bayesian probability, iterative model development, and hypothesis testing
• Experienced in developing and implementing novel methods, and going beyond packaged algorithms
• Experienced with analysis of genomic and epigenomic NGS data
• Comfortable designing and executing analyses in an open-ended, data-limited setting
• Experienced in the visualization of complex experiments to derive biological insights
• Strong ability in a high-level scripting language (Python/R; Python preferred)

Preferred

• Cancer biology background
• Experience in analyzing external genomic/epigenomic datasets (e.g. TCGA, ENCODE)
• Familiar with high-performance computing infrastructures (e.g., SGE, Spark)
• Experience leveraging AWS-based services (e.g., EC2, S3) to speed analyses

We would like to talk with you about our exciting projects and career paths.

Covid Vaccination Policy: Starting January 7, 2022, Guardant Health will require all employees to be fully vaccinated to either (a) establish that they have been fully vaccinated against COVID-19; or (b) request and obtain an approved exemption from Guardant's COVID-19 U.S. Vaccination Policy as a reasonable accommodation. An employee is considered fully vaccinated against COVID-19 two weeks after receiving the second dose of a two-dose vaccine or one dose of a single-dose vaccination. Acceptable vaccines are approved or under emergency use authorization by the U.S. Food and Drug Administration (FDA) and/or the World Health Organization (WHO). In addition, fully-vaccinated employees will be required to maintain their fully-vaccinated status under this Policy by obtaining, if applicable, any FDA-approved boosters.

#LI-MT1

Guardant Health is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.