Scientist, Medicinal Chemistry

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Job description

Work as part of an interdisciplinary drug discovery team to design and synthesize novel molecules for evaluation against ORIC's targets.

Responsibilities:

* Effectively design and synthesize drug candidates that advance SAR based on data analysis of biological, DMPK, and physicochemical properties data
* Work closely with the Medicinal Chemistry department and with the broader project teams to reach project milestones
* Efficiently execute the synthesis, purification and characterization of small molecules
* Develop and implement the design of synthetic routes to target compounds
* Analyze data, interpret results and recommend appropriate action
* Be a creative problem solver in the face of synthesis and project difficulties
* Keep abreast of recent scientific developments, patents and primary literature
* Prepare patent procedures and experimental write-ups, summaries and quantitative analyses
* Prepare presentation materials and clearly communicate research results at internal and external meetings
* Maintain a detailed laboratory notebook according to corporate standards and SOPs
* Participate in keeping the laboratory environment safe and well-organized

Qualifications & Experience:

* PhD degree in Organic or Medicinal Chemistry with 0-3 years of experience (or a Bachelor with 5-10 years of relevant experience in the pharmaceutical/biotech industry or Masters degree with 3-8 years of extensive industry experience and skills comparable to a PhD)
* Strong academic and practical background in modern synthetic, organic or medicinal chemistry
* Experience and scientific understanding of modern drug discovery technologies including, molecular modeling, DMPK, metabolism and physical properties is a plus but not required
* Demonstrated ability to work in a team environment and to multitask
* Strong communication skills and work ethic
* A commitment to continuous learning and a demonstrated ability to perform in a fast-paced environment with rapidly-changing priorities

About ORIC Pharmaceuticals:

ORIC Pharmaceuticals is a clinical stage biopharmaceutical company dedicated to improving patients' lives by Overcoming Resistance In Cancer. ORIC's lead product candidate, ORIC-101, is a potent and selective small molecule antagonist of the glucocorticoid receptor, which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors. ORIC-101 is currently in two separate Phase 1b trials of ORIC-101 in combination with (1) Xtandi (enzalutamide) in metastatic prostate cancer and (2) Abraxane (nab-paclitaxel) in advanced or metastatic solid tumors. ORIC's other product candidates include (1) ORIC-533, an orally bioavailable small molecule inhibitor of CD73, a key node in the adenosine pathway believed to play a central role in resistance to chemotherapy- and immunotherapy-based treatment regimens, and (2) ORIC-944, an allosteric inhibitor of the polycomb repressive complex 2 (PRC2) via the embryonic ectoderm development (EED) subunit being developed for prostate cancer. Beyond these three product candidates, ORIC is also developing multiple precision medicines targeting other hallmark cancer resistance mechanisms. ORIC has offices in South San Francisco and San Diego, California. For more information, please go to