Senior Director, Discovery Biology

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Job description

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Position

We are seeking a highly skilled and motivated cell biologist to support the mission of targeting E3 ubiquitin ligases in the areas of oncology. We are seeking a Senior Director responsible for managing biology functions for oncology R&D projects, from earliest screening efforts to the characterization of final IND candidates. This position will closely collaborate with medicinal chemist and in vivo pharmacology function. The candidate must be self-driven, organized, able to manage junior scientists, and able to thrive in an exciting environment in a rapidly growing company. This position will have the opportunity to influence the selection and development of a new wave of oncology targets for the company. The successful candidate must be motivated to lead teams of scientists to create new medicines for cancer patients.

Requirements:

• Must have a PhD or equivalent in cell biology or cancer biology, with 10-15 years of work experience.
• Have deep expertise in oncology and a strong background in small molecule drug discovery and lead optimization
• Proven track record in drug discovery and development with experience in small molecule drug candidate selection.
• Ability to manage multiple projects simultaneously.
• Ensure project success from discovery through IND filing.
• Experience with bi-functional degrader compounds is a plus.