Scientist (DMPK)

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Job description

Scientist (DMPK)
SSF, CA
POSITION SUMMARY:

Reporting to the Senior Fellow in the Department of Drug Metabolism & Pharmacokinetics (DMPK), this position contributes to the design and execution of specific bioanalytical and nonclinical ADME/PK projects in the DMPK area of expertise. As a member of the DMPK preclinical development team, the individual works primarily in drug research area and in the laboratory setting. In supporting numerous discovery projects, the Scientist works independently under minimal supervision and to be proactive in suggesting and implementing new analytical technology and workflow improvements.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

• Design, conduct and manage the execution of specific bioanalytical and ADME/PK (in vitro and in vivo) studies for multiple research and development programs.
• Develop bioanalytical assays (LC-MS/MS) for analysis of blood, plasma, urine and tissue samples for drug and metabolite concentrations.
• Prepare bioanalytical reports and presentations.
• Perform metabolism assays using hepatic microsomes or hepatocytes.
• Perform CYP450 inhibition/induction or drug transporter studies.
• Perform plasma protein binding assays.
• Perform Metabolite identification studies.
• Conduct in vitro and in vivo preclinical PK experiments, data analysis and reporting.
• Maintain data base for generated information.
• Evaluate and summarize data in a critical manner for dissemination to project team.

ADDITIONAL RESPONSIBILITIES:

• Presentation of data in group meetings or project team meetings.
• Interacting with other members of the group/project teams to discuss data.

KNOWLEDGE AND SKILL REQUIREMENTS:

• PhD 2 years of industry experience in Chemistry, Biochemistry, Pharmaceutical Science or a related field; or equivalent combination of degree and experience.
• Deep knowledge of drug metabolism, metabolite identification, CYP450 induction/inhibition assays, drug transporters, bioanalysis, ADME/PK from a variety of in vitro and in vivo matrices.
• Hands on drug metabolism and bioanalysis instrument operation experience
• Excellent communication, organization, and presentation skills are necessary
• Ability to conduct research both independently and in a team setting in a fast-paced environment.

WORKING CONDITIONS:

• PHYSICAL DEMANDS: While performing the duties of this job, the employee is required to stand, walk; sit; talk and hear. Specific vision abilities required by this job include close vision, distance vision, peripheral vision, depth perception and the ability to adjust focus.
• WORK ENVIRONMENT: The noise level in the work environment is usually moderate. There may be some potential exposure to hazardous materials. Some travel may be required.

Company Description:

About Ascent:

Ascent is a leading national technology consulting and professional services firm that focuses on tactical and strategic consulting. Ascent's fundamental business is providing staffing services to Large Enterprise clients in our core market verticals: Financial Services, Healthcare, and Life Sciences. We focus the majority of our efforts in Staff Augmentation support of Large Enterprise Clients who utilize a Vendor Management System. Ascent works as both a reliable supplier in support of programs, as well as a Strategic Advisor in support of enterprise efforts to establish best in class preferred vendor programs. Ascent was ranked in the 2007 and 2008 Inc. 500 and recognized specifically for its innovative work in staff augmentation support of Large Enterprise preferred vendor accounts.

If you are ready to propel your career to new heights… read on. We are looking for talented and dedicated colleagues to join our phenomenal team. At Ascent, we have created an environment where culture, commitment and opportunity converge to yield a truly unique place to work. We know that every employee has something important to say and that every employee is integral to our success. Where else can you walk over to a founder and talk about your ideas to help build our business and have that idea implemented in 48 hours? More importantly, we do everything we can to make sure our employees not only have great jobs, but great lives.