Scientist II Molecular Biology

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Job description

About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . on Twitter , Facebook , Instagram , YouTube and LinkedIn .

Since 2013, AbbVie has expanded its commitment to the San Francisco Bay Area with the consolidation of three Bay Area facilities to a new Bay Area headquarters in South San Francisco. AbbVie employees in the Bay Area drive AbbVie's research-based, innovation driven missions in healthcare. Specifically, Bay Area employees bring deep scientific expertise and commercial excellence to advance cancer care. Current oncology areas of focus include immuno-oncology, tumor targeting, tumor dependency and precision medicine. With facilities positioned in the heart of the biotechnology industry, we are able to collaborate with the best and brightest minds in oncology.

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products - Imbruvica, Venclexta, and Empliciti - and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer. AbbVie is expanding its oncology hub on the West Coast, with three sites in the San Francisco Bay Area (Redwood City, South San Francisco, and Sunnyvale) moving into a brand-new site in South San Francisco and focusing on the discovery and development of novel oncology therapies. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across these three sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie's new South San Francisco, CA location.

Scientist II Key Responsibilities

• Technical expert that will independently investigate, identify, develop and optimize new methods/ techniques to address critical project needs. Continuously seek to improve existing laboratory methods and processes. Read and adapt literature to accomplish assignments. Demonstrate mastery of broad range of experimental techniques and methods of data analysis. Design and perform biochemical and cellular studies of drug potency and mechanism of action.

Responsibilities:

• Independently design, execute and interpret critical experiments to answer scientific questions. Understand the broad objectives of the project as well as their role in achieving those objectives, and modify experimental plan when required, to respond.
• Learn, understand and master new experimental techniques, and act as a resource or mentor for others.
• Innovate and implement new experimental protocols.
• Demonstrate a high level of proficiency in his/her field.
• Set and meet experimental timelines.
• Effectively organize and present scientific plans and data.
• Contribute to writing and conceptual framework of publications, presentations, and patents.
• Routinely read and apply relevant scientific literature. Impact projects mostly through lab and/or pilot plant based activities where applicable.

Qualifications

• Experience in cell culture (suspension and adherent) and latest molecular and cellular biology assays including but not limited to DNA/RNA/protein purification, lentiviral transduction, CRISPR, RNAi, immunoprecipitation, WES, ELISA, MSD, qPCR, and colorimetric assays
• Expertise in multi-color immunophenotyping, flow cytometry and cell imaging techniques
• Experience with cell-based assay development, optimization, and troubleshooting
• Experience in establishing and fully validating compound potency assays using cell lines or primary human cells is essential. Experience in using cell biology models to elucidate molecular mechanisms of action
• Basic knowledge on biological data analysis tools (GraphPad Prism, FACS DIVA software, FlowJo, Image Studio, Compass) and computer applications such as MS Word, MS Excel and MS PowerPoint.
• Contribute to lab and equipment maintenance and help create a safe, effective, and efficient working environment.
• BS or equivalent education with typically 7 or more years of experience or MS or equivalent education with typically 5 or more years of experience.
• Demonstrated ability to independently design, execute and interpret critical experiments to answer scientific questions.
• Demonstrated ability to learn, understand and master new experimental techniques.
• Ability to multitask and work within timelines.
• Demonstrated scientific writing skills and strong verbal communication skills.

Significant Work Activities
N/A
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.