Scientist I - DMPK-BA: Drug Metabolism, Pharmacokinetics, and Bioanalysis - AbbVie Inc.

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Job description

About AbbVie
AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . on Twitter , Facebook , Instagram , YouTube and LinkedIn .

AbbVie's mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women's health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio.For more information about AbbVie, please visit us at .

The Drug Metabolism, Pharmacokinetics & Bioanalysis Department at AbbVie has an opening for a Scientist I position in North Chicago, IL. The successful candidate will be responsible for non-regulated quantitative LC-MS/MS bioanalysis of small molecules to support in-vitro HT-ADME studies, and in-vivo PKPD analyses for drug discovery and development.

Key Responsibilities Include:

• Perform quantitative LC-MS/MS (Liquid Chromatography Mass Spectrometry) analysis of small molecules from various in-vitro and in-vivo bio-matrices.
• Act as close partner of HT-ADME group, and multiple teams across DMPK-BA to provide bioanalytical support for ADME, PK/PD, efficacy, and exploratory toxicology studies.
• Operate, perform routine maintenance, and support the troubleshooting of SCIEX LC-MS/MS systems.
• Maintain excellent documentation of all work including electronic lab notebooks, test methods, and protocols.

Key Leadership Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.
• Learns fast, grasps the "essence" and can change course quickly where indicated.
• Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Qualifications

Basic:

• B.S. or M.S. in analytical chemistry or related field with 5+ (B.S.) or 2+ (M.S.) years of relevant academic/pharmaceutical industry experience.
• Hands-on experience with small molecule quantitative bioanalysis using LC-MS/MS is required.
• Experience in operating and troubleshooting current LC-MS/MS platforms (Agilent HPLCs, Leap/CTC PAL and ADDA autosamplers, Sciex API-5500/6500 triple quad mass spectrometers); familiarity with data acquisition and management software (e.g. Discovery Quant, Analyst, Electronic notebook).
• Working knowledge of sample preparation techniques. Familiarity of automated sample preparation platforms will be a plus.
• Knowledge of in-vitro HT-ADME assay (DDI/TDI, PPB, metabolic stability, etc.) development and analysis will be a plus.
• Detail oriented and committed to generating high-quality results within deadlines and across different projects.

Significant Work Activities
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Travel
No
Job Type
Experienced
Schedule
Full-time
Job Level Code
IC
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.