Computational Chemist

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Job description

Serqet Therapeutics is one of the latest companies founded through Flagship Pioneering's venture creation engine, where companies such as Moderna Therapeutics, Rubius Therapeutics, and Evelo Therapeutics were conceived and created. Since Flagship's founding in 2000, the firm has originated and fostered the development of nearly 100 scientific ventures resulting in $19+ billion in aggregate value, 500+ issued patents, and more than 50 clinical trials for novel therapeutic agents. Serqet Therapeutics is integrating the latest developments in computational and experimental biology to discover novel therapeutics for a broad range of diseases.

Serqet Therapeutics is seeking a capable and highly motivated Computational Chemist to join our growing team. As the computational chemist, you will be an essential part of an interdisciplinary team of highly creative and talented individuals responsible for setting and delivering on computational and medicinal chemistry strategies to impact project success at all stages from drug target identification through to clinical candidate nomination.

Responsibilities:

• Support all aspects of the company's computational chemistry efforts across therapeutic modalities, disease targets, and indications.

• Implementation of computational chemistry toolkits (e.g. MOE, MolSoft, OpenEye, Schrodinger) to run virtual screening campaigns to rapidly identify drug candidates for further development.

• Develop and implement computational chemistry approaches to design and triage compound ideas
• Work with a high degree of independence, to carry out structure and ligand-based design and data analysis
• Analyze all available data including biochemical and cellular SAR, ADME, and PK to drive analog designs to address key program challenges
• Collaborate with scientists from other disciplines including structural biology, biophysics, ADME/DMPK and safety sciences as part of the wider drug discovery project team.
• Discover and advance novel small molecule drugs into clinical development
• Provide strategic, scientific, and managerial leadership to medicinal chemistry team
• Define, implement, and execute on medicinal chemistry strategies
• Serve as chemistry lead (directly and/or indirectly) for discovery programs
• Collaborate with IP team to create and execute strategy to establish, protect and expand intellectual property
• Plan for and prioritize internal and external medicinal chemistry resources to achieve project goals
• Communicate, collaborate, and coordinate effectively with cross-functional teams
• Prepare, review, and deliver high quality scientific presentations for internal/external use
• Lead multidisciplinary drug discovery project teams in a fast-paced, results-driven biotech environment

Qualifications:

• Ph.D. degree in computational chemistry, or B.Sc./M.Sc with greater than 5 years' experience working as a computational chemist on predominantly small molecule drug discovery projects in a Pharmaceutical or Biotech setting
• Broad experience in structure and ligand-based design, data analysis and property prediction
• A passion for drug discovery and an excellent understanding of medicinal chemistry concepts
• Innovative problem-solver, with a track record of impacting drug project delivery
• Strong oral and written communication skills, team-working and time-management skills

This position will report to the Senior Vice President of Drug Discovery and will be responsible for driving medicinal chemistry efforts in a fast-paced small molecule discovery research team. The successful candidate will utilize their scientific and organizational leadership to advance small molecule drugs.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.