Senior Scientist/Associate Director, AAV production

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Job description

About BridgeBio Gene Therapy & BridgeBio Pharma

BridgeBio Gene Therapy, a subsidiary of BridgeBio Pharma, is focused on discovering and developing drugs for patients with grievous genetic diseases. We do this by:

Finding the right starting points to target diseases at their source.

Using a combination of a systematic assessment of the genetic disease landscape and informed diligence on the latest research, we find indications with clear mechanisms of pathogenesis that are ripe for translation into disease-modifying drugs.

Building products with world-class R&D personnel.

We employ industry-leading scientists that work closely with leading academics to prosecute a wide variety of drug programs at the highest level of scientific rigor. Our team combines biopharmaceutical veterans with up-and-coming leaders to drive entrepreneurial thinking grounded by experience.

BridgeBio is a biopharmaceutical company founded to discover, create, test and deliver transformative medicines to treat patients who suffer from genetic diseases and cancers with clear genetic drivers. We bridge the gap between remarkable advancements in genetic science in academic institutions and the delivery of meaningful medicines to patients. Founded in 2015, the company has built a portfolio of 30+ drug development programs ranging from preclinical to late-stage development in multiple therapeutic areas including genetic dermatology, precision oncology, cardiology, endocrinology, neurology, pulmonology, and renal disease, with two approved drugs.

Our focus on scientific excellence and rapid execution aims to translate today's discoveries into tomorrow's medicines. We have U.S. offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. We also have international offices in Montreal, Canada, and Zug, Switzerland, and are expanding across Europe.

To learn more about our story and company culture, visit us at

Who You Are:

The Senior Scientist/Associate Director; small-scale AAV production will oversee small-scale AAV production to support BridgeBio's growing gene therapy portfolio. The incumbent will report to the Senior Director, Development, and work closely with other team members to develop and evaluate new therapeutic candidates in preclinical models. This is a hands-on, laboratory-based research position in our Raleigh, NC laboratory.

Responsibilities:

• Design, develop and execute strategies to support AAV production for nonclinical research activities
• Optimize production yields and purification processes for novel capsids and transgenes in support of early-stage programs
• Keep up to date with the AAV field in general and especially developments related to AAV production
• Work closely with CMC colleagues to scale AAV production for more extensive campaigns
No matter your role at BridgeBio, successful team members are:


• Patient Champions, who put patients first and uphold strict ethical standards
• Entrepreneurial Operators, who drive towards practical solutions and have an ownership mindset
• Truth Seekers, who are detailed, rational, and humble problem solvers
• Individuals Who Inspire Excellence in themselves and those around them
• High-quality executors, who execute against goals and milestones with quality, precision, and speed

Education, Experience & Skills Requirements:

• BS/MS in biology, biochemistry, or related field with 5-10 years of experience or Ph.D. in biology, biochemistry, or related field with 2-5 years of experience
• Previous experience with AAV manufacturing is required
• A solid working knowledge of multiple AAV production platforms (bioreactors, WAVE rocker, shake flask) and production systems (HEK293, baculovirus) is essential for the success
• Must be able to think outside the box and tackle program specific challenges in a timely manner
• The ideal candidate will be goal focused and not distracted or discouraged by unforeseen challenges
• Strong interpersonal skills, good problem-solving skills, and effective written and oral communication are anticipated
• Experience with tech transfer will be beneficial

What We Offer:

• Patient Days, where we are fortunate to hear directly from individuals living with the conditions we are seeking to impact throughout the year and learn how we can improve our efforts
• A culture inspired by our values: put patients first, think independently, be radically transparent, every minute counts, and let the science speak
• An unyielding commitment to always putting patients first. Learn more about how we do this here
• A de-centralized model that enables our program teams to focus on advancing science and helping patients. Our affiliate structure is designed to eliminate bureaucracy and put decision-making power in the hands of those closest to the science
• A place where you own the vision - both for your program and your own career path
• A collaborative, fast-paced, data-driven environment where we inspire ourselves and each other to always perform at the top of our game
• Access to learning and development resources to help you get in the best professional shape of your life
• Robust and market competitive compensation & benefits package (Base, Performance Bonus, Equity, health, welfare & retirement programs)
• Flexible PTO
• Rapid career advancement for strong performers
• Potential ability to work on multiple BridgeBio Pharma programs across multiple therapeutic areas over time
• Partnerships with leading institutions
• Commitment to Diversity, Equity & Inclusion - with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels seen, valued, and heard

We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.