Scientist II

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Job description

Manager: Director, Gene Regulation
Department: Research
Location: Richmond, CA

Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms - gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. Using its deep scientific expertise and proprietary zinc finger genome engineering technology, Sangamo is working to create genomic cures for patients suffering from severe genetic diseases for which today's medicines can only treat symptoms. At Sangamo, we are passionate about transforming lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.

We are seeking top talent to join our mission. Let's build a better future together.

JOB SUMMARY:
Sangamo Therapeutics is seeking an innovative scientist to support the development of gene regulation and gene editing based therapeutics for central nervous system (CNS) diseases. The successful candidate will contribute to the creation and advancement of genomic medicines across our neurology pipeline. This is a highly-collaborative, hands-on position at the interface of discovery and translational research activities. The position requires creativity, organization, leadership, attention to detail, excellent communication and presentation skills, and a capacity for constant innovation in pursuit of company goals.

ESSENTIAL FUNCTIONS:

• Create and develop innovative solutions to challenging disease targets in the CNS using our zinc finger transcription factor (ZFP-TF) platform
• Generate in vitro and in vivo target engagement and efficacy data to support the advancement of CNS targets through all stages of preclinical development
• Perform, analyze and document laboratory procedures with exceptional attention to detail
• Manage and support research studies with academic partners and/or contract research organizations
• Supervise a small team of talented senior level research associates
• Closely collaborate with members of the discovery, technology, delivery and nonclinical teams
• Present results internally to R&D and executive leadership teams and externally at scientific conferences
• Publish results in leading scientific journals and contribute to related patent filings

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:

• Ph.D. in Molecular Neuroscience, Molecular Biology, Cell Biology, Bioengineering or related discipline
• 2+ years of relevant industry or post-doctoral experience. Level will be determined by experience, skills, and ability.
• Expertise in molecular biology including cloning, quantitative PCR, and next generation sequencing methods
• Proficiency in mammalian tissue culture, preferably primary and iPSC-derived neurons and glia
• Experience with high throughput assay design and implementation
• Experience working on gene regulation technologies a plus
• Experience working on prion, tau, alpha synuclein or related proteinopathy diseases a plus
• Experience working on transcriptional or chromatin biology a plus
• Experience in gene therapy and working knowledge of AAV is a plus

OTHER QUALIFICATIONS:

• Exceptional oral and written communication skills
• Exceptional interpersonal skills
• Ability to train and mentor research associates
• Ability to lead a project team as well as work independently
• Dedicated, hard-working, and dependable

Sangamo is an equal opportunity employer
The above reflects management's definition of essential functions for this position but does not restrict the tasks that may be assigned. The above duties are representative only; management may assign or reassign duties and responsibilities to this position at any time.

COVID-19

Sangamo requires all U.S. workers to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Sangamo, and it applies regardless of location or classification of role. If you are unable to receive the vaccine, you will have an opportunity to request a reasonable accommodation consistent with applicable laws.

Note to External Recruiters: Please understand that we do not accept unsolicited resumes from any source other than from the candidates themselves. Any agency or independent recruiter must have a signed copy of our agency agreement before presenting candidates. Submission of unsolicited resumes without our signed agreement will not create any implied obligation on our part.

If you wish to be considered for the presentation of candidates, please contact us through . Attach your contact information, your area of specialty, and any marketing information you wish to provide. Someone from the Talent Acquisition Department will contact you directly if there is a business need for your services.

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