Director Medicinal Chemistry

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Job description

YOH is seeking a Director of Medicinal Chemistry in San Francisco, CA, with pharmaceutical industry experience for a fulltime salary position. This person will contribute to all phases of the drug discovery, including HTS, hit identification, hit to lead, lead optimization, and candidate nomination. This Candidate will also interact with departments within and outside of the company making sure the day to day operations are run smoothly. The ideal candidate should have 5-10 years of industry experience or a PHD in Synthetic Organic chemistry.

Pay Rate: Based Upon Experience
Hours: Weekday Shifts
Industry: Pharmaceutical
Location: South San Francisco, CA
Type: Direct Hire

Primary Responsibilities:

• Design novel bioactive chemical entities in alignment with project goals based on the SAR analysis and by applying medicinal principles and tools.
• Employ sound judgment in the evaluation and strategic decision making on HTS hits and subsequent hit optimization follow-up.
• Advance drug discovery programs by collaboratively interacting with other cross-functions to understand and optimize DMPK and in vitro and in vivo pharmacological properties.
• Effectively manage external CRO chemists through strong synthetic and medicinal chemistry skills.
• As needed, contribute to chemistry program strategy or serve as chemistry project lead for drug discovery programs.
• Work closely with biologists to evaluate new programs and provide input on chemical tractability and analysis of literature leads.
• Present results of work, interprets data, and draws conclusions regarding presented material and nature of work.
• Contribute effectively to patent, report and scientific publication writing.

Requirements:

• Ph.D. in synthetic organic chemistry or medicinal chemistry with 5-10 years pharmaceutical industrial experience in small molecule drug discovery and development.
• Excellent understanding of medicinal chemistry concepts and execute strategies across all stages of drug discovery process to achieve program goals.
• Proven track record in medicinal chemistry as evidenced by successful advancement of drug discovery projects is desirable.
• Good understanding with structure-based drug design concept is desirable.
• Exceptional understanding of physicochemical, ADME, biochemical, pharmacology principles and effectively applying these in the design of novel small molecule drugs and toward successful project advancement.
• Demonstrate a high level of creativity and productivity with strong synthetic problem-solving skills. Have clear command of organic synthesis and conversant with the current literature.
• Experience in managing external chemistry resources.
• Collaborate and communicate across a dynamic multi-disciplinary scientific team to successfully progress scientific goals.
• Excellent written and oral communication skills including ability to present the rationale, data, issues and accomplishments of the team.

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