Senior Scientist/ Principal Scientist of Protein Expression

---

Job description

Reports To: Associate Director of Protein Production, Generate Biomedicines

Location: Andover, MA (primary); Cambridge, MA (secondary)

The Company:

Generate Biomedicines, Inc. is a Flagship backed, privately-held biotechnology company on a mission to reimagine the drug discovery process to one of deterministic, data-driven generation. We pursue this audacious vision because we believe in the unique and revolutionary power of generative biology to radically transform the lives of billions, with an outsized opportunity for patients in need. Generate will be successful by constantly turning innovative ideas into methods, technologies, and therapeutics that solve some of the most difficult challenges with developing medicines. We are seeking collaborative, relentless problem solvers that share our passion for impact to join us!

Generate was founded by Flagship Pioneering. Flagship Pioneering conceives, creates, resources, and develops first-in-category life sciences companies to transform human health and sustainability. Since its launch in 2000, the firm has applied a unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $30 billion in aggregate value. The current Flagship ecosystem comprises 37 transformative companies, including: Moderna Therapeutics (NASDAQ: MRNA), Rubius Therapeutics (NASDAQ: RUBY), Indigo Agriculture, and Sana Biotechnology.

The Role:

Generate is seeking an experienced, highly motivated, and innovative Senior Scientist/ Principal Scientist of Biotherapeutics Expression to contribute to the development of our drug discovery platform and to drive delivery of our therapeutic pipeline. She/he will be responsible for performing transient and stable protein expression using various host cell and cell-free systems across a range of different protein modalities, supporting our growing portfolio of projects. She/he will also be responsible for managing a small team of research associates and scientists performing protein expression.

Responsibilities:

• Perform transient and stable protein expression of various protein modalities, with an emphasis on antibodies.
• Build and lead a small team of scientists and research associates across multiple sites performing protein expression.
• Manage all protein expression activities in group being accountable for planning, prioritization, and on-time delivery of generated protein variants.
• Efficiently accomplish project goals on time and budget, tracking capacity constraints and resource use within team.
• Contribute to Process Development and CMC activities at Generate, specifically cell line development activities.
• Serve as a subject matter expert in recombinant protein production to different cross-functional teams.
• Detailed documentation of experiments and data on our internal LIMS systems, electronic notebook and presentations to project teams.

Required Skills/Experience:

• PhD, MS or BS in science-related discipline
• Minimum of 4 years PhD/ 8yrs MS/ 10 yrs BS (Sr Sci) or 8 yrs PhD/ 12 yrs MS/ 14 yrs BS (Prin Sci) of biologics expression experience in a biotech/pharma setting
• Experience with standard mammalian expression systems (HEK/CHO) including stable cell line development workflows.
• Track record of helping to deliver biotherapeutic assets to clinical development
• 2+ years of management experience
• Excellent communication, attention to detail, documentation and technical writing skills
• Familiarity of regulatory issues pertaining to the manufacture of biologics

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.