Associate Scientist I

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Job description

Job Description

Duties:

The successful candidate will be part of the ocular research group within the CNS group in the Research Department and will be responsible for ocular in vivo pharmacology activities. The candidate will be involved in the design and execution of small-animal pre-clinical activities to evaluate RNAi compounds for ocular therapeutic indications.

Skills:

Execute in vivo studies to support a variety of ocular research efforts including target validation and RNAi platform advancements.
The candidate will work as part of an interdisciplinary research group, helping evaluate new routes of ocular administration (intracameral, intravitreal, topical etc) to enable Client genetic target validation and enable proof of concept for Client conjugates.
Coordinate with key expertise areas to generate necessary reagents for in vivo screening.
Develop and conduct assays that support in vivo studies (e.g. qPCR, ELISA, cell based assays) for the quantitative analysis of biomarkers.
Perform in vivo PK/PD studies to understand siRNA activity, MOA and metabolism
Prepare clearly articulated experimental reports and data presentations
Qualifications Requirements include a bachelor or masters in an appropriate biological discipline such as pharmacology, genetics or molecular/cellular biology. 1-5 years of hands-on ocular in vivo experience in an academic or industrial setting along with significant prior supervisory experience would be required.
Experience working with oligonucleotides and RNAi would be a plus.
The candidate must be self-motivated, able to lead and thrive in a team environment and be comfortable working on and prioritizing multiple projects.
The candidate should have strong verbal and written communication skills and be capable of routinely interpreting data and making presentations to diverse groups within Research and Development.