Director/Sr. Director, DMPK

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Job description

Company Summary:

Founded in 2017 within Flagship Labs, Cellarity's new approach to drug discovery is based on the computational modeling of cell behavior, leading to a more complete understanding of system and network biology to uncover cell-behavior-targeted medicines for a wide variety of diseases. Cellarity recently raised $123 million in Series B financing. The round included contributions from funds and accounts managed by BlackRock, The Baupost Group, Banque Pictet on behalf of their clients and eight other investors alongside Flagship Pioneering.

Cellarity is generating unprecedented biological insights by combining its unique expertise in network biology, high-resolution data, and machine learning. The result is a new understanding of the cell's trajectory from health to disease, and how cells relate to one another in tissues. Because the cell and its network of transcripts and proteins offer a more complete view of the complexity of human biology than any individual molecular target, Cellarity's approach allows for more efficient drug discovery and is designed to drive higher rates of clinical success. Already, the company has seven drug discovery programs underway in diverse therapeutic areas that range from metabolic disease to immuno-oncology.

The successful Series B financing round validates the strength of Cellarity's science and its potential to redefine drug discovery through its cell-centric approach.

Position Summary:

Cellarity is seeking a highly motivated and innovative Director/Senior Director with expertise in the field of DMPK to play a vital role in the company's efforts to validate novel discovery approaches based on cell behavior. The candidate will be working under the supervision of the Head of Chemistry and will be responsible for establishing robust ADME science across the lifespan of a project from initiation to the clinic in close collaboration with Medicinal chemistry, Machine Learning (ML) and Biology teams, to therapeutically manipulate healthy and diseased cell states and rapidly advance discovery programs within our discovery portfolio. They will be comfortable working in and contributing to a very dynamic and cross-functional team environment. The ideal candidate must be independent, results oriented, with excellent communication skills and be willing to work in a highly dynamic and fast-paced entrepreneurial environment.

Key Responsibilities:

• Serve as a DMPK expert on various discovery teams on strategies for early ADME profiling and interpretation of the data.
• Define strategy for in vitro DDI and other in vitro/in vivo DMPK assessment for individual preclinical drug candidates and ensure timely availability of key data
• Strategically design and lead ADME, PK and PD studies, critically analyze and interpret data, identify issues and help overcome experimental challenges.
• Establish PK-PD-efficacy correlations to guide preclinical study design,
• Contribute to selection of preclinical tox species and develop toxicokinetic plan to support IND for our programs
• Prepare human dose projections based on preclinical data to guide candidate selection.
• Author ADME/DMPK sections of IND/IB
• Closely interact with external CROs, stakeholders within and outside Cellarity for questions beyond the candidate's area of expertise

Basic Qualifications:

• Ph.D. in pharmaceutical science, biochemistry, or related scientific discipline with years or MS/BS with 15+years of relevant experience in DMPK in the biopharmaceutical industry or CROs supporting pharmaceutical development, preferably with a focus on small molecules
• Demonstrated DMPK skills through high quality publications
• Hands-on experience with small molecule drug discovery in different therapeutic areas
• Excellent communication skills.
• Strengths in the following areas: creativity, problem-solving, and managing relationships within a matrix project team environment (internal/external partners).
• Demonstrated ability to successfully work in cross-functional teams with an emphasis on teamwork, collaboration, and communication within team and across the department

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.