Investigator I (mRNA Construct Design)

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Job description

Job Description

Job Summary:

This position will be responsible for designing, building, and testing platforms for multivalent mRNA-based vaccine development. This position will work closely on designing, screening and testing mRNA elements for most stable and potent mRNA vaccine platform.

Major Accountabilities:

Platform development for mRNA.

• Design, build, and test seasonal and pandemic flu mRNA vaccines in the form of mono- and multi-cistronic format.
• Design, build, screen and test functional RNA elements or expression strategies in the non-coding and coding region of mRNA vaccine.
• This person independently generates practical experimental designs and steps to achieve scientific goals, to develop new protocols or introduce novel systems that serve to accomplish scientific goals.

Documentation and presentation of scientific results.

• Write experimental protocols and prepare internal reports. Maintain lab notebooks.
• Collaborate with project teams, present research results and contribute to technical advancements and publications.

Lab management.

• Maintain functional laboratory equipment and keep up with ordering and lab organizing.

Other job duties that may be assigned from time to time.

• The candidate should be agile in supporting other activities in the MMB and other functions, including but not limited to idea generation and assay supports.

Minimum Requirements:

• PhD degree in molecular biology, RNA biology or related fields required;
• PhD with 3-5+ years of postdoc experience preferred in academia and industry experience molecular biology or RNA biology.
• Experienced in enabling multi-cistronic expression in post transcriptional and/or post translational settings is required.
• Working experience of DNA construct design and production is required.
• Working experience with mRNA, with training in RNA biology is required: such as knowledge of RNA structure, base modifications, novel RNA capping, RNA tails, splicing, intron, RNA elements, RNA folding, RNA half-life, untranslated regions, or aptmers, etc.
• Experience in synthetic biology is a plus.
• Experience of cell-based reporter assays is a plus.
• Previous experience in the flu or vaccines field is desired.

About Us

Our Benefits

Seqirus is committed to attracting and retaining world-class employees who are valued for their contributions to achieving business objectives. Learn more about some of the benefits you can participate in when you join Seqirus.

About Seqirus

Seqirus is part of CSL Limited (ASX: CSL). As one of the largest influenza vaccine providers in the world, Seqirus is a major contributor to the prevention of influenza globally and a transcontinental partner in pandemic preparedness. Learn more about Seqirus .

We want Seqirus to reflect the world around us

As a global organisation with employees in 35+ countries, CSL embraces diversity, equity and inclusion. Learn more about Diversity, Equity & Inclusion at Seqirus.

Do work that matters at Seqirus!