Process Development Engineer/Research Associate (Downstream)

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Job description

Company Overview

CRISPR Therapeutics is a leading gene editing company focused on developing transformative gene-based medicines for serious diseases using its proprietary CRISPR/Cas9 platform. CRISPR/Cas9 is a revolutionary gene editing technology that allows for precise, directed changes to genomic DNA. CRISPR Therapeutics has established a portfolio of therapeutic programs across a broad range of disease areas including hemoglobinopathies, oncology, regenerative medicine, and rare diseases. To accelerate and expand its efforts, CRISPR Therapeutics has established strategic collaborations with leading companies including Bayer, Vertex Pharmaceuticals and ViaCyte, Inc. CRISPR Therapeutics AG is headquartered in Zug, Switzerland, with its wholly-owned U.S. subsidiary, CRISPR Therapeutics, Inc., and R&D operations based in Cambridge, Massachusetts, and business offices in San Francisco, California and London, United Kingdom.

Job Summary

If you like a challenge, love to learn and want to be part of a team developing the next generation of gene editing biotherapeutics based on CRISPR/Cas9, we would like to hear from you. Our ideal candidate will have hands-on technical experience with downstream process development for the manufacture of biologics and with an understanding of bioprocess engineering principles. The position will be responsible for downstream purification of recombinant viruses and will be a key member of the team developing expression and purification strategies for novel gene editing/gene therapy vectors.

Responsibilities

• Contribute to a smart, integrated development approach for definition of scalable viral vector processes and suitable control strategies.
• Plan and perform experiments to develop/characterize purification process steps including chromatography (affinity, IEX, HIC, SEC, etc.) and filtration (depth filtration, UFDF, and sterile filtration).
• Perform experiments for process characterization to develop control strategies for downstream unit operations using DoE, multivariate analysis, and other statistical tools.
• Manufacture critical materials for developmental and preclinical testing.
• Participate in tech-transfer activities with CMOs.
• Organize work and complete individual objectives as part of a team to maintain project timelines and provide updates on project status in team meetings by oral presentations.
  
  

Minimum Qualifications

• BS (2+ yrs. for Eng II, RA II, or 4+ yrs for Eng III, Sr. RA) or MS (Eng II, RA II, or 2+yrs for Eng III, Sr. RA) in a relevant scientific discipline (e.g., Biological or Chemical Engineering, Biology, Virology) with experience in bioprocess development.
• Hands on experience with downstream purification of biologics - especially for viral vectors: adeno associated virus (AAV), lentivirus.
• Experience in bioprocess unit operations: centrifugation, depth filtration, chromatography (ion exchange, size exclusion, affinity), tangential flow filtration, and sterile filtration.
• Desire to take on new technology challenges and broaden technical skill set, including upstream bioreactor manufacture of viral vectors and/or product characterization/analysis.
• Application of advanced automation and statistical data analysis in development, including design of experiments (DoE) is a plus.
• Excellent verbal and written communication skills.
• Ability to work independently and effectively in team-oriented environment; driven and highly organized, attention to details.
  

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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