Senior/Principal Scientist, RNA Molecular Biology

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Job description

Company Summary:

Laronde is an early-stage biotechnology company with the mission to become the leader in the development of nucleic acid medicines by leveraging its multi-modality eRNA platform. Our modular Endless RNA™ (eRNA) platform, will be supported by a large-scale digital and manufacturing infrastructure with the bold vision of 100 new medicines within the next decade. With eRNA, we're making new therapeutics that will become essential medicines of the future to address unmet needs across multiple disease areas. Check out for more information on our vision.

Laronde was founded by Flagship Pioneering, a team of entrepreneurial scientists that conceives, creates, resources and grows first-in-category life sciences companies. Since 2000, Flagship has created over 100 groundbreaking companies pioneering novel and proprietary biological, industrial and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna Therapeutics (MRNA), Seres Therapeutics (MCRB), Syros Pharmaceuticals (SYRS), Rubius Therapeutics (RUBY), Evelo Biosciences (EVLO), Kaleido Biosciences (KLDO) and Indigo Agriculture.

Position Summary:

Laronde is seeking an outstanding Senior/Principal Scientist, RNA Molecular Biology to join a multidisciplinary team of experimental and computational synthetic biologists and engineers responsible for study, design and optimization of novel endless RNA (eRNA) therapeutics. The ideal candidate will lead experimental efforts to characterize eRNA structure in vitro and inside living cells in a high-throughput manner through applying the world-class chemical probing tools coupled with next-generation sequencing (NGS) technologies. If you are a passionate and purposeful scientist keen on testing your hypotheses and learning from some of the best synthetic biologists and engineers whilst getting to work with complex multidimensional data sets, then we are looking for you.

Key Responsibilities:

• Develop and apply novel chemical probing methods to interrogate eRNA structural features in a variety of contexts and to understand the eRNA sequence-structure-function relationships
• Work closely with an interdisciplinary team of experimental and computational biologists to design experiments, analyze data, interpret and present your results at company meetings and strategic program readouts

• Work with automated liquid handlers for high throughput NGS library preparation
• Carefully document experiments in an electronic lab notebook and communicate results to collaborators
• Work effectively with High-throughput Pharmacology, Chemistry, Therapeutic areas, Discovery Biology, and Manufacturing teams to drive discovery and development efforts
• Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences
• Work closely within an entrepreneurial, highly-collaborative, interdisciplinary, and fast-paced environment and willingness to change the status quo

Qualifications:

• PHD in Molecular Biology, Biochemistry or a related field with 5+ or 12+ years of post-doctoral experience in academia or industry for Senior and Principal Scientist, respectively
• Strong expertise in RNA biochemistry and RNA structural biology
• Experience with chemical probing (e.g., SHAPE-MaP) is a strong plus
• Expertise in NGS library preparation, bulk and single-cell RNA sequencing, and analysis of RNA-binding protein interactions
• Experience culturing mammalian cell lines and primary cells
• Drug discovery experience in the field of RNA Therapeutics within industry or academy is preferred
• Peer-reviewed publications that can showcase your skills
• Demonstrated ability in working with highly skilled teams in a fast-paced, entrepreneurial and technical environment

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, "FSP") do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering's internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.