Senior Scientist, Molecular Biology

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Job description

Why Patients Need You

Pfizer's purpose is to deliver breakthroughs that change patients' lives. Research and Development is at the heart of fulfilling Pfizer's purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting edge design and process development capabilities to accelerate and bring the best in class medicines to patients around the world.

What You Will Achieve

As a Senior Scientist, you will be at the center of our operations and you'll find that everything we do, every day, is in line with an unwavering commitment to quality. You will join a team responsible for the generation of monoclonal antibodies as tool reagents for antigen and vaccine candidate characterization as well as for development of assays for clinical testing and other downstream activities. The focus will be on development of antibodies through hybridoma fusion and demonstration of functional activity. Duties will include Molecular Biology support to the team, including cloning and sequencing of mAb heavy and light chains using standard and next generation technologies. You will also support the team in hybridoma fusion and selection and development of desired clones. Your ability to work in team and matrix settings, write reports, standard operating procedures (SOPs) and contribute to publications for peer review is required.

You will be recognized as a technical expert and a scientific contributor. With your deep knowledge of the discipline, you will be an active team member whose decisions impact the project. You will be using your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will be forecasting and planning resource requirements for your project team. Your creativity in developing novel processes and new ideas will be used frequently. You will undertake mentoring activities to guide team members.

It is your innovative scientific temperament that will help in making Pfizer ready to achieve new milestones and help patients across the globe.

How You Will Achieve It

• Execute experiments to generate monoclonal antibodies through hybridoma technology to support the goals of program teams.

• Pioneer novel technologies for development, screening, selection and characterization of desired hybridoma clones and mAbs.

• Support all Molecular Biology efforts to support the team, including cloning and sequencing using standard and novel technologies.

• Interface with other groups/project teams (internal, external, customers, CROs) to identify need for monoclonal reagents and define timelines and scheduling to meet project goals

• Demonstrated capability of multitasking project tasks and their priorities; handle various tasks in parallel while demonstrating problem solving skills in the planning and execution of objectives.

• Interpret and summarize experimental data. Participate in the evaluation of new methods or technologies.

• Present experimental results at group meetings, project meetings, and department meetings, as required.

• Prepare research reports and SOPs; contribute to writing of publications and regulatory documents.

• Maintain laboratory notebook in a detailed and descriptive manner.

BASIC QUALIFICATIONS:

• PhD with 3 years postdoctoral or industrial experience, MS with 6 years relevant experience (industry preferred), BS with >10 years relevant experience (industry preferred) including antibody, molecular biology and/or immunology experience.

• Molecular Biology experience required, including vector design and familiarity with current cloning strategies/methodologies.

• Experience with hybridoma technology including hands-on-skills in the performance of fusions as well as downstream screening and characterization activities for the generation of monoclonal antibodies in mice and rabbits.

• Extensive experience in cell culture work with various mammalian cell lines, including transfection and transient expression.

• Hands-on experience in protein analytics such as ELISA, Luminex, Octet/Biacore, and/or Flow cytometry (FACS).

• Ability to write independently and develop SOPs, reports, internal communication as well as sound presentation skills to present scientific data internally.

• Understanding of relevant work in the scientific literature and ability to apply the information to improve internal processes and/or establish new procedures/technologies.

• Proficiency with Microsoft Office applications and relevant scientific software, including and graphing/statistical analysis tools is expected.

• The candidate must possess excellent verbal and written communication skills.

PREFERRED QUALIFICATIONS:

• Experience with Next Generation sequencing platforms preferred.

• Experience with monoclonal antibody heavy and light chain cloning and sequencing a plus.

PHYSICAL/MENTAL REQUIREMENTS

Sitting, standing, walking, light lifting (

NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS

Travel to regional, national meetings/trainings, etc. Adherence to safe work practices and procedures required.

OTHER JOB DETAILS:

• Eligible for Relocation Package

• Eligible for Employee Referral Bonus

• #LI-PFE

Pfizer requires all U.S. new hires to be fully vaccinated for COVID-19 prior to the first date of employment. As required by applicable law, Pfizer will consider requests for Reasonable Accommodations.

Sunshine Act

Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative.

EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.

Research and Development