Associate Scientist - Biomarkers

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Job description

Associate Scientist - Biomarkers
United States - Washington - Seattle

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company's five core values. That's because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible


Associate Scientist/Sr. Associate Scientist

We are seeking a highly motivated individual with broad assay development and validation experience to join the Biomarker Assay Technology Team within the Biomarker Sciences Department. This individual will develop and validate biomarker assays using various technologies including ligand binding, nucleic acid, enzymatic, and flow cytometry methods to support clinical programs across all therapeutic areas at Gilead. This position is a location dependent, Seattle based position.

Specific Responsibilities and Skills

• Independently develop assays to measure biomarkers in biological tissues and fluids, gather input from colleagues and translate the information into assay requirements; qualify assays to support clinical trials across multiple therapeutic areas
• Identify high quality CROs to transfer methods, critically evaluate CRO data
• Design experimental plans to address specific scientific questions, to resolve biomarker assay development/qualification issues and project needs
• Identify and select the most appropriate technology or methods to answer complex questions; identify CROs to expand available technology.
• Suggest best practices for clinical sample collection to reduce impact of pre-analytical variables on biomarker measurements.
• Interpret experimental data critically and propose next steps.
• Draft assay procedures, qualification reports, and coordinate, when needed, with CRO laboratories on assay transfer and troubleshooting.
• Broad laboratory experience including experience with ligand binding assays (ELISA, MSD, Luminex, Ella, Quanterix), multi-parameter flow cytometry, gene expression assays (rtPCR, Nanostring, RNAseq, scRNAseq), enzymatic assay and other techniques (Western blot, immunoprecipitation, etc.) is required. Experience with mass spectrometry, "-omics" data analysis, and/or bioanalytical assays is preferred.
• Experience working with human and/or animal tissues and samples is preferred.

Essential Functions

• Independently plans and executes assigned experiments that support non-routine research activities to achieve project goals.
• Applies advanced level of technical and biologic understanding to project goals and methods.
• Selects appropriate methods and techniques when performing experiments.
• Analyze and interprets data; design new experiments to advance scientific knowledge of drug substances or techniques to identify such substances.
• Recommends alternatives, researches new methods and techniques and may proactively seek out senior personnel to discuss potential solutions to problems.
• May lead functional group meetings. Presents results of work, interprets data, and draws conclusions regarding presented material and nature of work.
• Works independently and determines methods and techniques on new or difficult assignments.
• Works on complex problems where analysis of situations or data requires comprehensive evaluation of many factors.
• Acts as a resource for other employees within the department.
• Maintains high level of expertise through familiarity with scientific literature and applies appropriately to research projects.
• Uses strong communication skills (both verbal and technical) and interpersonal skills to communicate objectives and results.
• Must think critically and creatively and be able to work independently, determine appropriate resources for resolution of problems and have strong organizational and planning skills.

Knowledge, Experience and Skills

• 9+ years of experience with BS degree or 8+ years of experience with MS degree in a related scientific discipline.
• Excellent verbal communication and interpersonal skills are required; must be able to communicate effectively internally in Biomarker Sciences and with other Gilead functional groups in Research and Development.
• Must be able to multi-task through work on a number of diverse projects at the same time.
• Experience in biomarker assay development, fit-for-purpose qualification/validation, and analysis of clinical samples is highly desired.
• Strong laboratory experience using multiple biochemical and assay techniques is required.
• Experience in translational sciences or preclinical biomarker discovery/validation is preferred.
• Experience with validating bioanalytical assays is preferred.
• Experience implementing a broad array of platforms and technologies to support a clinical research program is preferred.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact for assistance.

Following extensive monitoring, research, consideration of business implications and advice from internal and external experts, Gilead has made the decision to require all U.S. employees and contractors to receive the COVID-19 vaccines as a condition of employment. "Full vaccination" is defined as two weeks after both doses of a two-dose vaccine or two weeks since a single-dose vaccine has been administered. Anyone unable to be vaccinated, either because of a sincerely held religious belief or a medical condition or disability that prevents them from being vaccinated, can request a reasonable accommodation.

For more information about equal employment opportunity protections, please view the 'EEO is the Law' poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

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