Scientist, Analytical Development (Separations)

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Job description

Scientist, Analytical Development (Separations)

We are currently seeking a self-motivated, passionate, and accomplished Scientist to join
our Analytical Development team. You will play a significant role in analytical method
development and characterization of therapeutic proteins expressed using our proprietary E. coli expression platform. You will explore new and innovative
technologies, oversee the routine instrument operation and maintenance, and train and
mentor junior personnel and personnel from other teams. The responsibilities of this role
will utilize your interpersonal and strong written and verbal communication skills for
multi-disciplinary collaboration with the other teams, including Molecular
Sciences, Fermentation, Purification, and Bioinformatics. You bring a passion for scientific
innovation, excellent technical skills, and you execute your responsibilities with high
attention to detail and a sense of urgency You thrive in a team dynamic in a
high-performance culture.

Responsibilities:

• Develop and execute laboratory tasks to support the development, optimization, and sample analysis of complex biologics by various chromatographic and electrophoretic separations techniques such as LC (e.g. LC-UV, SEC, IEX, etc.) and CE-SDS, including associated sample preparation techniques (e.g. desalting, sample concentration, protein denaturation or oxidation, etc.).
• Operation, maintenance, and installation of sophisticated chromatography instrumentation (e.g. HPLC, CE, etc.)
• Write and review formal reports, including method SOPs, reports, and other technical documents
• Evaluate data for trends indicative of product performance, method performance, and/or analyst performance and present internally to team members and senior management
• Evaluate new technologies and platforms
• Use of software packages such as LIMS, ELNs (electronic lab notebooks), EMPOWER, JMP, etc.
• Lead, mentor, and inspire junior team members
• Support internal technical teams, including R&D, fermentation and purification process development teams
• Maintain accurate documentation of all work in laboratory notebooks

Qualifications:

• PhD in Analytical Chemistry, Biochemistry, or related scientific discipline degree
• Comprehensive hands-on knowledge of protein analytics and characterization, including LC (e.g. LC-UV, SEC, IEX, etc.) and CE-SDS
• Experience in sample preparation techniques including desalting, buffer exchange, proteolytic digestion, deglycosylation, reduction, alkylation, etc.
• Experience in the operation, maintenance, and troubleshooting of associated instrumentation
• Ability to design and execute experiments; review and interpret data
• Excellent problem-solving and troubleshooting skills
• Experience in using software packages such as LIMS, ELNs (electronic lab notebooks), EMPOWER, JMP, etc., is preferred

Huge plus (but not required):

• Post-doctoral and/or industry experience preferred
• Previous experience with SDS-PAGE, Western blot, ELISA, BLI, SPR, and/or LC-MS is preferred
• Previous experience with automation and high-throughput screening is preferred
• Previous experience in the analysis of ADCs and/or glycans is a plus
• Experience in using software packages such as LIMS, ELNs (electronic lab notebooks), EMPOWER, JMP, etc., is preferred

Company Description:

About Ascent:

Ascent is a leading national technology consulting and professional services firm that focuses on tactical and strategic consulting. Ascent's fundamental business is providing staffing services to Large Enterprise clients in our core market verticals: Financial Services, Healthcare, and Life Sciences. We focus the majority of our efforts in Staff Augmentation support of Large Enterprise Clients who utilize a Vendor Management System. Ascent works as both a reliable supplier in support of programs, as well as a Strategic Advisor in support of enterprise efforts to establish best in class preferred vendor programs. Ascent was ranked in the 2007 and 2008 Inc. 500 and recognized specifically for its innovative work in staff augmentation support of Large Enterprise preferred vendor accounts.

If you are ready to propel your career to new heights… read on. We are looking for talented and dedicated colleagues to join our phenomenal team. At Ascent, we have created an environment where culture, commitment and opportunity converge to yield a truly unique place to work. We know that every employee has something important to say and that every employee is integral to our success. Where else can you walk over to a founder and talk about your ideas to help build our business and have that idea implemented in 48 hours? More importantly, we do everything we can to make sure our employees not only have great jobs, but great lives.