Associate Scientist

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Job description

About Servier Pharmaceuticals:

We're an organization, committed to modelling diversity, equity, and inclusion for the entire industry. We are interested in growing our team with passionate, committed, and innovative individuals. We encourage all to apply to our open roles and are always willing to consider skills and experiences outside of what is listed in the job description.

SUMMARY OF ROLE:

Servier is seeking to hire someone to help drive novel target ID and validation in cancer biology, with a focus on immune oncology. This is a lab-based position within the functional genomics team to help devise and execute novel CRISPR screens and apply genetic engineering tools to drive early target validation. The candidate will contribute to novel discovery and work across Servier's multidisciplinary team to help define our future oncology portfolio.

Specific Responsibilities:

1. Perform cell-based assays to assess the impact of small molecule inhibitors, shRNAs, or CRISPR-mediated knockouts on cancer cells and/or immune cells.

2. Perform mechanistic studies to characterize the cellular pathways impacted by inhibition of novel cancer and/or immune targets.

3. Run CRISPR genome wide screens to identify and explore novel targets in the tumor driver and I/O space

4. Collaborate with internal and external research groups. Work cross functionally across the international organization

5. Document, analyze, and interpret results to be presented in group settings.

Skills and Education:

1. PhD in cell & molecular biology or related discipline with 0-3 years of industry/academic experience in the field. BS/MS with 2+ years of experience considered.

2. Demonstrable scientific engagement and initiative with an excitement for a lab-based role.

3. Prior experience with genetic manipulation of mammalian cells (e.g. CRISPR, shRNA).

4. Knowledge in cancer biology.

5. Excellent organizational and communication skills with the ability to work in a collaborative environment.

Preferred Skills:

1. Experience with lentivirus and/or electroporation-mediated genetic manipulation of cancer cells and immune cells

2. Experience in immunology assays with primary immune cells (includes cell isolation, tissue culture, cell activation and cytokine detection).

3. Experience in multi-color flow cytometry.

4. Experience with ex-vivo assays (syngeneic tumor mouse models).

5. Experience with pooled or arrayed CRISPR screening including library design.

Job Type: Full-time

Pay: From $74,686.00 per year

Benefits:

• 401(k)
• 401(k) matching
• Dental insurance
• Employee assistance program
• Flexible schedule
• Flexible spending account
• Health insurance
• Health savings account
• Life insurance
• Paid time off
• Parental leave
• Referral program
• Relocation assistance
• Retirement plan
• Tuition reimbursement
• Vision insurance

Schedule:

• Monday to Friday

Experience:

• Research: 2 years (Preferred)

Work Location: One location